CKD519, a selective inhibitor of cholesteryl ester transfer protein(CETP), is undergoing development as an oral agent for the treatment of primary hypercholesterolemia and mixed hyperlipidemia.The aim of this study was to predict the appropriate efficacious dose of CKD519 for humans in terms of the inhibition of CETP activity by developing a CKD519
In the present study, we attempted to control the Hayward Navigator Parts pH profile of the catalytic activity of the industrially relevant alkaline protease KP-43, by incorporating 3-nitro-l-tyrosine and 3-chloro-l-tyrosine at and near the catalytic site.Thirty KP-43 variants containing these non-natural amino acids at the specific positions were
Abstract The adipokinetic hormone (AKH) of insects is considered an equivalent of the mammalian hormone glucagon as it induces fast mobilization of carbohydrates and lipids from the fat body upon Lip brush starvation.Yet, in foraging honey bees, which lack fat body storage for carbohydrates, it was suggested that AKH may have lost its original func
The density of herbaceous crops creates a suitable environment to produce pathogens in the soil that intensify the attack of pathogens traditionally controlled by disinfectant, which are mostly prohibited and unlisted because of their toxicity.Grafting is an alternative technique to enhance abiotic stress tolerance and reduce root diseases due to s
The use of the ban on exile during the Qajar period was used to dispose of the influential person from the center.The princes and dwinnians were from this group of exiles.Meanwhile, the exile of the constitutional era is an exception.Because on both sides of the constitutional and oppositional constitutional movements they were seeking change in po